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Mathrax (162)
Instruction:
Place a digit from 1 to 8 into each of the empty cells so that each digit appears exactly once in each row and column. Some intersections of the grid lines are marked by a number and an operator (+, -, x, /) in a circle. The number is the result of the operation, applied to both pairs of diagonally opposite cells within the 2x2 area. An "E" in the circle indicates that all four neighbouring digits are even, while an "O" indicates that all four neighbouring digits are odd.